PMOS Awareness Month: how Genus Medical Fertility can support you
By Dr. Karolina Skorupskaite Carlyle, Founder of Genus Medical Fertility
Polyendocrine Metabolic Ovarian Syndrome (PMOS), formerly known as Polycystic Ovary Syndrome (PCOS), is one of the most common hormonal and metabolic conditions, affecting approximately one in ten women of reproductive age. Despite being a leading cause of infertility, it remains widely misunderstood.
As a fertility specialist, one of the most frequent conversations I have with patients begins when they are trying to conceive. Living with irregular cycles or facing difficulties getting pregnant, many women arrive seeking specialist advice, assuming their diagnosis dictates their entire reproductive future.
PMOS can influence ovulation, hormone balance, and metabolism. It is typically characterised by a combination of irregular or absent ovulation, hormonal imbalances, polycystic ovarian morphology on ultrasound, and, in some cases, features of insulin resistance.
However, PMOS affects every woman differently. Some may experience mild symptoms, while others face more significant reproductive or metabolic concerns. Symptoms can range from irregular, infrequent, or absent periods to acne, oily skin, excess body hair, scalp hair thinning, or weight gain.
Because symptom severity varies so considerably, a generic, one-size-fits-all approach to care simply does not work.
The primary reason PMOS affects fertility is through the disruption of normal ovulation. Infrequent or absent ovulation makes conception less predictable.
While many women with PMOS conceive naturally, others experience difficulties. However, a diagnosis of PMOS does not automatically mean someone will require intensive fertility treatment. The reassuring news is that fertility care for PMOS is often highly successful, particularly when regular ovulation can be restored.
How Genus Medical Fertility supports your journey
At Genus Medical Fertility, we believe every patient deserves care tailored to their unique circumstances, symptoms, and fertility goals. We provide a comprehensive assessment and individualised treatment roadmap designed to optimise your fertility safely and effectively:
- Thorough diagnostic assessment: We begin with a detailed review of your medical history, symptoms, and goals. Investigations include comprehensive hormone blood tests, pelvic ultrasound scans, AMH (Anti-Müllerian Hormone) testing, thyroid function assessments, prolactin testing, and metabolic evaluations where appropriate.
- Targeted, evidence-based treatments: Care pathways are tailored directly to you. Options range from lifestyle optimisation and weight management support to Metformin for selected patients. When medical intervention is required, ovulation induction using Letrozole or other medications is often our first-line approach, offering high success rates. Where indicated, advanced treatments such as IVF are also available.
- Individualised safety protocols: Women with PMOS can face a higher risk of ovarian hyperstimulation during fertility treatments. At Genus, our treatment protocols are carefully individualised to minimise this risk while maximising your chances of achieving a successful pregnancy.
PMOS Awareness Month offers an opportunity to deepen the conversation. True awareness goes beyond simply recognising the condition, it is about understanding just how uniquely PMOS impacts every individual.
Our role as clinicians is not to apply a standard template, but to listen, understand what matters to you, and use the best available evidence to guide your care.
