Polyendocrine Metabolic Ovarian Syndrome (formerly PCOS)

Polyendocrine Metabolic Ovarian Syndrome (PMOS), previously known as Polycystic Ovary Syndrome (PCOS), is one of the most common hormonal conditions affecting women of reproductive age and a leading cause of infertility.

PMOS can affect ovulation, hormone balance and metabolism. While many women with PMOS conceive naturally, others may experience difficulties due to irregular or absent ovulation.

At Genus Fertility, we provide comprehensive assessment and personalised fertility treatment for women with PMOS, helping optimise fertility and improve the chances of achieving pregnancy.

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Ovulation disorders treatment in Edinburgh

Polyendocrine Metabolic Ovarian Syndrome (formerly PCOS)

PMOS can affect ovulation, hormone balance and metabolism. While many women with PMOS conceive naturally, others may experience difficulties due to irregular or absent ovulation.

At Genus Fertility, we provide comprehensive assessment and personalised fertility treatment for women with PMOS, helping optimise fertility and improve the chances of achieving pregnancy.

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What is PMOS?

PMOS is a hormonal and metabolic condition that affects approximately one in ten women. The condition is characterised by a combination of:

Irregular or absent ovulation
Hormonal imbalance
Polycystic ovarian morphology on ultrasound
Features of insulin resistance in some women

PMOS affects women differently. Some experience only mild symptoms, while others may have more significant reproductive, hormonal or metabolic concerns.

Symptoms of PMOS

Symptoms may include:

Irregular menstrual cycles
Infrequent periods
Absent periods
Difficulty conceiving
Excess facial or body hair
Acne or oily skin
Weight gain or difficulty losing weight
Thinning hair on the scalp
Polycystic ovarian morphology on ultrasound

Not every woman will experience all of these symptoms, and symptom severity varies considerably.

How Does PMOS Affect Fertility?

The most common reason PMOS affects fertility is through the disruption of normal ovulation.

Women with PMOS may ovulate infrequently or not at all, making conception less predictable. In addition, some women may experience hormonal and metabolic changes that can further influence reproductive health.

The good news is that fertility treatment for PMOS is often highly successful, particularly when ovulation can be restored.

Diagnosing PMOS

Diagnosis begins with a detailed review of your symptoms, menstrual history and fertility goals.

Investigations may include:

Hormone blood tests
Pelvic ultrasound scan
AMH testing
Thyroid function assessment
Prolactin testing
Metabolic assessment where appropriate

Diagnosis begins with a detailed review of your symptoms, menstrual history and fertility goals.

Treatment for PMOS

Treatment is tailored to your individual circumstances, fertility goals and any additional fertility factors.

Treatment options may include:

Lifestyle optimisation
Weight management support where appropriate
Metformin in selected patients
Ovulation induction using Letrozole or other fertility medications
IVF treatment where indicated

Ovulation induction is often the first-line fertility treatment for women with PMOS-related infertility and is highly effective for many patients.

Women with PMOS may have an increased risk of ovarian hyperstimulation during fertility treatment. At Genus Fertility, treatment protocols are carefully individualised to minimise this risk while maximising success.

FAQs

Can I get pregnant naturally with PMOS?

Yes. Many women with PMOS conceive naturally. However, irregular ovulation can make conception less predictable and may increase the time taken to achieve pregnancy.

Is PMOS the same as PCOS?

Yes. PMOS (Polyendocrine Metabolic Ovarian Syndrome) is the updated terminology increasingly used in place of Polycystic Ovary Syndrome (PCOS).

How successful is ovulation induction?

Ovulation induction is one of the most effective fertility treatments for women with PMOS. Success rates depend on age, BMI, ovarian reserve and the presence of any additional fertility factors.

Will I need IVF?

Not necessarily. Many women conceive following ovulation induction alone. IVF is generally reserved for women who do not conceive with simpler treatments or where additional fertility factors are present.

Can weight loss improve fertility?

For women who are overweight, even modest weight reduction may improve ovulation and fertility outcomes. However, treatment recommendations are always individualised and based on your overall health and fertility goals.

Polyendocrine Metabolic Ovarian Syndrome (formerly PCOS)

Polyendocrine Metabolic Ovarian Syndrome (formerly PCOS)

What is PMOS?

Symptoms of PMOS

How Does PMOS Affect Fertility?

Diagnosing PMOS

Treatment for PMOS

FAQs

Start your journey with Genus Fertility today.

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